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SANTA CLARA https://www.49ersfanshop.com , Calif. (AP) — San Francisco 49ers running back Jerick McKinnon had another setback in his return from a knee injury.General manager John Lynch told flagship radio station KNBR on Wednesday that McKinnon’s return to practice the previous day was “not encouraging.” Lynch said McKinnon’s recovery regressed for the third time this summer as he has tried to get back on the field.McKinnon tore his right ACL a week before the start of last season. He had a flare-up right before the start of training camp and began on the physically unable to perform list. McKinnon was activated on Aug. 6 and went through two light practices before another setback sidelined him for three weeks.McKinnon returned to practice again Tuesday but had another setback.“It’s a real bummer because you keep getting to the final step and the final step is actually playing NFL football, and particularly at his position, where you have to make hard cuts, you have to put your foot in the ground, and we did it a month ago and he kind of regressed and I would say yesterday we had a similar situation San Francisco 49ers Customized Jerseys ,” Lynch told the radio station. “So we’re trying to get to what’s the root cause of the problem that he’s having. And just because he’s working through it, I’m going to leave it at that, but yesterday was not encouraging from that standpoint for Jet. What that means, we’re not sure yet, but we’re working hard to find that out.”The Niners could place McKinnon on season-ending injured reserve or put him on the initial 53-man roster Saturday and then place him on IR San Francisco 49ers T-Shirts , leaving the option for him to return after eight weeks.McKinnon was one of the team’s major acquisitions in free agency in 2018, signing a four-year, $30 million contract but he has yet to play a game for San Francisco because of injuries.The 49ers have depth at running back with free-agent acquisition Tevin Coleman having the most playing experience over his career. He has been a key part of Atlanta’s offense the past few years.Matt Breida, who averaged 5.3 yards per carry last season, had seven carries for 44 yards and a 20-yard TD catch last week against Kansas City and also figures to be in the rotation.Special teams standout Raheem Mostert has also fared well as a running back this preseason with 100 yards from scrimmage at Denver in San Francisco’s second exhibition game.Reserve Jeff Wilson has also played well with 21 carries for 78 yards and three TDs in the preseason but San Francisco might not have room for four running backs on the roster.In other injury news https://www.49ersfanshop.com/hats , Lynch said No. 2 overall pick Nick Bosa could possibly return as early as the season opener against Tampa Bay on Sept. 8 from an ankle injury. The defensive end sprained his ankle in practice on Aug. 7. SANTA CLARA, Calif. (AP) — San Francisco 49ers free safety Adrian Colbert likely will miss the rest of the season with a high ankle sprain he suffered Sunday.The 49ers placed Colbert on injured reserve Monday and signed quarterback Tom Savage to a one-year contract to take his roster spot.Coach Kyle Shanahan estimated Colbert would be sidelined for six to eight weeks. He would be eligible to come off IR for the 49ers’ second-to-last game, at home against the Chicago Bears on Dec. 23.But Shanahan talked as if Colbert, a second-year player out of Miami, will be shut down for the season. Rookie D.J. Reed will get the first opportunity to start at free safety in his absence.“It’s tough. It’s part of football San Francisco 49ers Hoodie , though,” Shanahan said. “It’s not the first time that’s happened. Colbert is one of those guys who got his opportunity last year because a lot of guys went down.”The 28-year-old Savage, who made nine starts over three seasons with the Houston Texans, originally signed with San Francisco last Tuesday. He was waived Saturday when the 49ers promoted defensive back Tyvis Powell from the practice squad for Sunday’s game against the Rams because of injuries in the secondary.But Savage was quickly re-signed to provide San Francisco with a third quarterback alongside starter C.J. Beathard and backup Nick Mullens. The 49ers lost Jimmy Garoppolo in Week 3 to a torn ACL.Shanahan remained firmly committed to Beathard on Monday despite a shaky performance in Sunday’s 39-10 loss to the Rams.Beathard threw two interceptions and lost a fumble, giving him seven interceptions and three lost fumbles in five games (four starts). San Francisco (1-6) is winless since Beathard took over for Garoppolo.“We’ve had 18 turnovers this year Y.A. Tittle Jersey ,” Shanahan said. “I’ve watched every single one, definitely more than once. I recommend you guys (the media) do it too. You guys will see there’s a lot of people involved in each one.”The 49ers have an NFL-worst minus-15 turnover ratio, and the offense is only half the problem. San Francisco has forced just three turnovers — one interception and two fumbles — in seven games.Colbert is one of a few second-year defensive players — linebacker Reuben Foster and cornerback Ahkello Witherspoon are others — who haven’t made the impact that was anticipated after their promising rookie seasons.Addressing his group of second-year defenders as a whole, Shanahan said: “Those guys worked extremely hard in the offseason. They came in ready to take it to another level and they haven’t done that so far. That stuff’s hard.”Shanahan praised Colbert, however https://www.49ersfanshop.com/Steve-Young-Jersey , saying the free safety was enjoying a strong game Sunday before hurting his ankle while trying to intercept interception on a deep pass in the third quarter.NOTES: Running back Matt Breida is day-to-day after tweaking his left ankle Sunday, but “his strength is good,” Shanahan said. … Receivers Marquise Goodwin (ankle) and Pierre Garcon (knee) and strong safety Jaquiski Tartt (stinger) will be evaluated Wednesday. … Foster (shoulder) is expected to practice Wednesday.