What is the mechanism of action of Avana 50 Mg?

[Ronymeran]

Avana 50 mg contains the active ingredient avanafil, which is a medication used to treat erectile dysfunction (ED). Avanafil belongs to a class of drugs known as phosphodiesterase type 5 (PDE5) inhibitors.

The mechanism of action of Avana 50 (avanafil) involves its ability to inhibit the enzyme phosphodiesterase type 5 (PDE5). This enzyme is primarily found in the smooth muscle cells of the corpus cavernosum in the penis. The corpus cavernosum is a spongy tissue that fills with blood during sexual arousal, leading to an erection.

When a man is sexually stimulated, nitric oxide is released in the corpus cavernosum, which activates an enzyme called guanylate cyclase. Guanylate cyclase produces cyclic guanosine monophosphate (cGMP), which acts as a second messenger, causing smooth muscle relaxation and increased blood flow into the penile arteries. This increased blood flow results in an erection.

However, the enzyme PDE5 breaks down cGMP, leading to a decrease in its levels and relaxation of the smooth muscle. By inhibiting PDE5, Avana (avanafil) helps to maintain higher levels of cGMP in the corpus cavernosum, prolonging the effects of nitric oxide and promoting stronger and longer-lasting erections.

In summary, Avana 50 mg works by enhancing the natural physiological process of penile erection, allowing men with ED to achieve and maintain satisfactory erections during sexual activity. It's important to note that Avana (avanafil) requires sexual stimulation to be effective and does not cause erections on its own.